The definition for polycystic ovarian syndrome varies, but the one adopted by the RCOG is 2 of 3 of:
- Polycystic ovaries (12 or more peripheral follicles or ovarian volume >10cm^3)
- Oligo or anovulation
- Clinical and/or biochemical signs of hyperandrogenism (hirsuitism, acne, alopecia)
Features associated with polycystic ovarian syndrome include:
- Polycystic ovaries
- Obesity (40-50% of patients)
- Acanthosis nigricans
- Increased risk of
- Type 2 diabetes
- Obstructive sleep apnoea
- Raised LH (40% of women)
- Raised testosterone
- Low or normal FSH
- Lifestyle changes to encourage weight loss
- OCP to block androgen effects
- Topical eflornithine hydrochloride (an inhibitor of the enzyme ornithine decarboxylase) for hirsuitism
- Clomifene if fertility issues
- ?ovarian drilling
Badawy, A. and Einashar, A. Treatment options for polycystic ovary syndrome. Int J Womens Health. 2011; 3:25-35.
Balen, A. and Rutherford, A. Managing anovulatory infertility and polycystic ovary syndrome. BMJ. 2007. 335(7621): 663-666.
Conway, G. and Jacobs, H. Acanthosis nigricans in obese women with the polycystic ovary syndrome: disease spectrum not distinct entity. Postgrad Med J. 1990; 66(777): 536-538.